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| Egypt J Pediatr Allergy Immunol |
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2022 |
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20 |
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61 |
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68 |
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ESP - 340 |
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Original articles |
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| Preschool wheeze among a retrospective cohort of Egyptian children |
| Zeinab A. El-Sayed |
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Rasha H. El-Owaidy |
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Ghada O.M. Wassif |
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Roba M. Al-Gaweesh |
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Ghada A. Shousha |
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| Background: The prevalence of recurrent wheezing in preschool age was
reported to affect one-third of children in the developed world, with even
more frequency and severity in developing countries. Epidemiological
studies on this subject in Egypt are lacking. We sought to investigate the
frequency and different phenotypes of preschool wheeze (PSW) among a
group of Egyptian children and their relation to various risk factors.
Methods: A retrospective cohort study was conducted on 1209 children,
aged 6-10 years, recruited from the Outpatients’ Clinics of Ain Shams
University Hospitals from March 2019 to March 2021. Children with
underlying chronic disease or suspected to be immunodeficient were
excluded. The main study tool was a survey composed of 30 questions and
presented to the parent/caregiver via direct interviewing by the investigator
and included sociodemographic data details of wheezing episodes before the
age of 6, wheezing risk factors, and comorbidities. Skin prick test (SPT) was
done for the prolonged early, persistent early and late-onset wheezers, while
pulmonary function tests were done for the current asthmatics patients.
Results: The history of PSW was positive in 298/1209 (24.6%)
participants. According to the onset, duration, and course of wheezes,
preschool wheezers were classified as transient wheezers (10.4%),
prolonged early wheezers (3.9%), late-onset wheezers (3.2%) and persistent
wheezers (7.1%) relevant to the whole cohort. Fifty percent of PSW were
multi-trigger wheezes while 39.3% were episodic viral wheezes. Twenty-five
patients out of 148 wheezers (16.9%) who underwent SPT were found to be
atopic. Conclusion: PSW is commonly reported among Egyptian children,
paralleling international reports with transient and persistent early
wheezing being the most common phenotypes in Egypt. |
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