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| Egypt J Pediatr Allergy Immunol |
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2022 |
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ESP - 329 |
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Review article |
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| Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE |
| Elham M. Hossny |
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Mohammad A. Sharaf |
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Nancy Samir Wahba |
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Abdulrahman A. Warsame |
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| There is substantial evidence that lupus nephritis (LN) is primarily related to type-III hypersensitivity reactions leading to immune complex deposition at the mesangial, subendothelial, and/or subepithelial space near the renal glomerular basement membrane. The search for a non-invasive urinary marker of lupus nephritis is an appealing point of research. There are few studies that have evaluated the role of urinary ceruloplasmin (CP) as a biomarker for LN. Being expressed at high levels by parietal epithelial cells of Bowman’s capsule it could possibly detoxify molecules as they pass through the glomerular filter. CP is a highly effective antioxidant that can prevent oxidative damage to lipids, DNA, and proteins. However, it is unlikely that a single biomarker can replace clinical parameters to monitor disease progression and detect early renal flares. |
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