Egypt J Pediatr Allergy Immunol, (April 2022), Volume No. 20, Issue 01  
Egypt J Pediatr Allergy Immunol 2022 ; 20 ( 01 ) : 3 - 6
, ESP - 329  
Review article
Value of Urinary Ceruloplasmin as a Marker in Juvenile SLE
Elham M. Hossny   Mohammad A. Sharaf   Nancy Samir Wahba   Abdulrahman A. Warsame      
There is substantial evidence that lupus nephritis (LN) is primarily related to type-III hypersensitivity reactions leading to immune complex deposition at the mesangial, subendothelial, and/or subepithelial space near the renal glomerular basement membrane. The search for a non-invasive urinary marker of lupus nephritis is an appealing point of research. There are few studies that have evaluated the role of urinary ceruloplasmin (CP) as a biomarker for LN. Being expressed at high levels by parietal epithelial cells of Bowman’s capsule it could possibly detoxify molecules as they pass through the glomerular filter. CP is a highly effective antioxidant that can prevent oxidative damage to lipids, DNA, and proteins. However, it is unlikely that a single biomarker can replace clinical parameters to monitor disease progression and detect early renal flares.