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| Egypt J Pediatr Allergy Immunol |
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2012 |
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10 |
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13-18 |
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ESP - 21 |
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Original articles |
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| Platelet activating factor and monocyte chemoattractant protein-1 in
children with refractory epilepsy |
| Sahar A. Abd El-Aziz |
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Rasha A. Alm El-Din |
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| Background: Epilepsy is an important common and diverse group of
symptom complexes characterized by recurrent spontaneous seizures. It is
estimated that about 5-10% of all cases of epilepsy eventually become
refractory. It has been suggested that inflammation plays a role in epilepsy.
In refractory epilepsy, an inflammatory response is produced that leads to
rapid release of pro-inflammatory cytokines as platelet activating factor
(PAF) and monocyte chemoattractant protein-1 (MCP-1).
Objective: The aim of the present study was to evaluate the plasma levels of
the monocyte chemoattractant protein-1 (MCP-1) and platelet activating
factor (PAF) in children with refractory epilepsy to explore their role in the
pathogenesis of refractory epilepsy.
Methods: The present study was carried out in Tanta University Hospital,
Pediatric Department, Neurology unit. Forty (40) children with idiopathic
refractory epilepsy (25 males and 15 females) their age ranging between 4-
15 years were included in the study. The control group consisted of thirty
healthy children, 20 males and 10 females aged 5 years to 13 years. The
serum levels of MCP-1 and PAF were measured for children with refractory
epilepsy and the control children. Results: Children with refractory epilepsy
had significantly higher serum levels of PAF (P value<0.001) and
significantly higher serum level of MCP-1 (P value<0.001) in comparison to
the control children. Also there was a significant correlation between the
duration of refractory epilepsy and the serum levels of PAF and MCP-1.
Conclusion: Higher serum levels of the proinflammatory cytokines PAF and
MCP-1 in children with refractory epilepsy suggest that both, PAF and
MCP-1, may play a role in the pathogenesis of refractory epilepsy. |
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