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EG |
Download |
| Egypt J Pediatr Allergy Immunol |
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2012 |
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10 |
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01 |
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3-12 |
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ESP - 20 |
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Review article |
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| Antihistamines in pediatric allergy |
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| Histamine is a key mediator in allergic diseases,
where it exerts most of its effects through the H1
receptor and to a less extent the H2 receptor. H1-
antihistamines provide rapid relief of many of the
allergic symptoms and are considered the main
stay of treatment of allergic rhinoconjunctivitis
and urticaria. H1 antihistamines comprise first
generation (old) and second generation (new) H 1
antihistamines with different pharmacological
aspects, efficacy and safety profile. Few studies
dealt with H1 antihistamines in pediatric
population. This review will highlight the
characteristics of H1 antihistamines and their
indications in pediatric allergic disorders. |
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