| 1 |
|
Download |
| Egypt J Pediatr Allergy Immunol |
|
2015 |
; |
13 |
( |
02 |
) |
: |
45 |
- |
48 |
|
, |
ESP - 209 |
|
Original articles |
|
| Hepatitis B Virus Vaccine immune response in Egyptian children 15-17
years after primary immunization; should we provide a booster dose? |
| Mohammed Eladawy |
|
Amira Gamal |
|
Ahmed Fouad |
|
Amel El- Faramawy |
|
|
|
|
|
|
| Background: Few studies have evaluated the seroprotection of HBV
vaccines among healthy Egyptian children after receiving the primary
immunization. Yet, up to our knowledge none of them has evaluated the
immune status to HBV vaccine among Egyptian children older than 15
years.
Objective: To assess the seroprotection as well as immunological memory
against HB virus more than 15 years after receiving the primary set of
vaccination.
Methods: Serum anti-HB surface antibody was measured in 225 healthy
adolescents. Their ages ranged from 16-18 year with a definite history of
receiving the primary immunization for HBV at infancy. A booster dose of
the HB vaccine was given to 56 of the candidates in whom serum level of
anti-HB surface antibody was not protective (less than 10 mIU/ml). A
second evaluation of anti-HBs was done in those 56 one month after the
booster dose.
Results: Only 8.9% of our cohort have a protective anti-HBs antibody when
measured 15-17 years after primary vaccination set. On the other hand,
100% of the 56 children who received the booster dose showed excellent
anamnestic response.
Conclusion: Despite the loss of protective levels of anti-HBs antibody
among healthy low risk adolescents 15-17 years after primary HB
immunization set, strong anamnestic response indicates the presence of
good immunological memory. |
| |