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| Egypt J Pediatr Allergy Immunol |
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2015 |
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13 |
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02 |
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39 |
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44 |
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ESP - 208 |
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Original articles |
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| Neutrophil functions in late preterm neonates with respiratory distress
syndrome |
| Yehia El-Gamal |
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Rasha H. El-Owaidy |
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Mohammed T. Hamza |
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Reem A. Elfeky |
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Mohammed E. Abdel-Galil |
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| Background: Studies that have addressed the effects of respiratory distress
syndrome (RDS) on neutrophil function suggested that neutrophil functions
other than the generation of the respiratory burst are not impaired. Yet,
results have been confusing and in some cases contradictory. Objectives:
The aim of this cross-sectional controlled study is to assess neutrophil
number and function in late preterm neonates with RDS. Methods: Thirty
patients underwent clinical and laboratory evaluation including complete
blood counts and tests of neutrophil functions (CD11b, CD62L and
Dihydrorhodamine 123 by flowcytometry) in comparison to 15 healthy term
controls. RDS was assessed clinically and radiologically (chest x-ray).
Results: Fifty percent of patients (12 females and 18 males) had grade II
respiratory distress followed by grade III then grade I. DHR, CD 11b and
CD62L results were lower among the patients group (mean ± SD: 62.1±
12.23, 63.22 ± 11.41, 15.03 ± 8.7 respectively). There were no significant
correlations between neutrophils count, DHR, CD11b and CD62L. Only
CD11b was significantly lower with higher grades of RDS. Conclusion:
Neonates with RDS show variable affection of neutrophil functions. Further
studies are recommended to elucidate the exact mechanisms by which RDS
can affect neutrophil functions and whether these effects are associated with
increased incidence of infections. |
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