Egypt J Pediatr Allergy Immunol, (April 2016), Volume No. 14, Issue 01  
Egypt J Pediatr Allergy Immunol 2016 ; 14 ( 01 ) : 15 - 21
, ESP - 197  
Original articles
Serum vitamin D and IgE levels in infants and children under 2 years of age with recurrent chest wheeze
Osama M. El-Asheer M.D.   M. S. K. Tawfeek M.D.   Nafisa H.R.Abd Aziz M.D.   Manal M. Darwish PhD   Madleen A. Abdou M.D.   Khalid A. Sanousy  
Background: Wheezing is a very common complaint on admission to the pediatric emergency department. There is an increasing awareness of the important role of VD in the maintenance of immune system, recurrent wheezing and respiratory health.Objective: Estimate serum VD, IgE levels and eosinophilic count in infants and children under 2 years of age with recurrent wheeze. Method: Case-control prospective study on 85 infants (58 male and 27 female), ranging in age from 6-24 months, diagnosed to have recurrent wheeze (>3 attacks), were recruited from the Pediatric Emergency Department (patient group) and 85 were age-and-gender matched healthy infants with no history of wheeze (control group). Blood samples were taken from both groups to determine serum VD level, IgE level, and eosinophil count. Results: Serum VD of patients were significantly lower than those of controls (p = 0.001), whereas serum IgE and eosinophil counts of patients were significantly higher than those of controls (p <0.0001 for both). Serum levels of VD correlated negatively with the number of wheeze attacks and hospitalization. Conclusion: The study findings revealed lower serum VD levels in infants with recurrent wheeze and provides additional evidence supporting the hypothesis that VD has a role in infant wheeze. VD supplementation might be practical and favorable for better control of recurrent infant wheeze.