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EG |
Download |
| Egypt J Pediatr Allergy Immunol |
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2012 |
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10 |
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02 |
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95-100 |
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ESP - 17 |
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Original articles |
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| Allergic bronchopulmonary aspergillosis as a cause of bronchial asthma in
children |
| Dina Shokry |
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Ashgan A. Alghobashy |
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Heba H. Gawish |
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Manal M. El-Gerby |
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| Background: Allergic bronchopulmonary aspergillosis (ABPA) occurs in
patients with asthma and cystic fibrosis. When aspergillus fumigatus spores
are inhaled they grow in bronchial mucous as hyphae. It occurs in non
immunocompromised patients and belongs to the hypersensitivity disorders
induced by Aspergillus. Objective: To diagnose cases of allergic
bronchopulmonary aspergillosis among asthmatic children and define the
association between the clinical and laboratory findings of aspergillus
fumigatus (AF) and bronchial asthma. Methods: Eighty asthmatic children
were recruited in this study and divided into 50 atopic and 30 non-atopic
children. The following were done: skin prick test for aspergillus fumigatus
and other allergens, measurement of serum total IgE, specific serum
aspergillus fumigatus antibody titer IgG and IgE (AF specific IgG and IgE)
and absolute eosinophilic count. Results: ABPA occurred only in atopic
asthmatics, it was more prevalent with decreased forced expiratory volume
at the first second (FEV1). Prolonged duration of asthma and steroid
dependency were associated with ABPA. AF specific IgE and IgG were
higher in the atopic group, they were higher in Aspergillus fumigatus skin
prick test positive children than negative ones .Wheal diameter of skin prick
test had a significant relation to the level of AF IgE titer. Skin prick test
positive cases for aspergillus fumigatus was observed in 32% of atopic
asthmatic children. Conclusion: ABPA occurs in 1/3 of atopic asthmatic
children and is related to the duration and severity of asthma. |
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