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EG |
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| Egypt J Pediatr Allergy Immunol |
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2013 |
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11 |
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15-21 |
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ESP - 7 |
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Original articles |
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| Serum interleukin 27: a possible biomarker of pediatric systemic lupus
erythematosus |
| Yehia M. El-Gamal |
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Dalia H. El-Ghoneimy |
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Dina A. Soliman |
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Mona M. Mohamed |
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| Background: Systemic lupus erythematosus (SLE) is a complex
autoimmune disease; different cytokines play a role in the
immunopathogenesis of SLE. IL-27 has both immunosuppressive and
pro-inflammatory roles and its role is unclear in SLE.
Objectives: To measure serum interleukin (IL)-27 among a group of
patients with pediatric SLE (pSLE) and whether it varies with SLE
clinical and laboratory features or with therapy.
Methods: Fifty patients with pSLE and 25 healthy subjects were
included. Routine laboratory and immunological markers of SLE were
done. Serum IL-27 was measured by enzyme linked immunosorbent assay
for both patients and healthy subjects.
Results: Serum IL-27 was significantly lower in patients when compared
to healthy subjects (p< 0.001); 17 patients (34%) had low serum IL-27
(serum IL-27 < 160 pg/ml). Patients in lupus flare and those in
remission had comparable levels (p> 0.05). Serum IL-27 did not vary
significantly between patients with lupus nephritis (LN) and those
without evident LN, moreover, it was comparable among different
histological classes of LN (p> 0.05). The disease status in terms of SLE
disease activity index was comparable among lupus patients with normal
serum IL-27 and those with decreased serum IL-27 (p> 0.05). Serum IL-
27 was not affected significantly with the cumulative doses and the types
of the immunosuppressive drugs used (p> 0.05).
Conclusion: Decreased serum IL-27 in SLE might support its
involvement in the immune alteration underlying SLE but its exact role
remains unclear. |
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