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EG |
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| Egypt J Pediatr Allergy Immunol |
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2013 |
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11 |
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35-40 |
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ESP - 10 |
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Original articles |
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| Oxidant-antioxidant balance in childhood asthma |
| Dina M. Shokry |
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Shereen A. El-Tarahony |
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| Background: Asthmatic patients generate reactive oxygen species
impairing the antioxidant defense system and creating a state of
oxidative stress in asthmatics. Objectives: Determination of the oxidant
- antioxidant status in asthmatic children, by measuring the activities of
antioxidant enzymes; superoxide dismutases (SOD) and glutathione
peroxidases (Gpx) and estimating plasma level of malondialdehyde
(MDA) as an index of lipid peroxidation, to find a relation between
antioxidant levels and the severity of asthma and the early response to
treatment. Methods: This study included 60 children; group (1): 40
asthmatic children and group (2): 20 apparently healthy children as a
control group. The following were measured in all the children; plasma
level of (MDA), erythrocytes (SOD) and (Gpx) (in asthmatic children two
samples were taken; the first during acute attack and the second after 48
hours of treatment). Results: Significant lower erythrocyte antioxidant
enzymes activities and higher malondialdehyde was found in asthmatic
children compared to the control group, either before or after receiving
treatment. In asthmatics, MDA was significantly decreasing and SOD
was significantly increasing with treatment. MDA was significantly
higher, while SOD was significantly lower with the severity of asthma
either before or after receiving treatment. A significant negative
correlation was observed between MDA with both of SOD and Gpx, in
acute asthmatic attacks. A significant positive correlation was detected
between the activities of SOD and Gpx enzymes. Conclusion: Acute
asthma leads to a considerable oxidative stress that is indicated by the
high level of malondialdehyde and low level of antioxidant enzymes. |
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