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EG |
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| Egypt J Pediatr Allergy Immunol |
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2012 |
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10 |
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02 |
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87-94 |
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ESP - 14 |
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Original articles |
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| Vitamin D supplementation and the risk of infections in fullterm infants:
Correlations with the maternal serum vitamin D |
| Abdel-Azeem M. El-Mazary |
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Mohamed Abdel-Maaboud, |
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Mo`men MM |
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Khaled A. Nasef |
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| Background: Recently, epidemiologic and genetic studies suggest a vital
and complex role of vitamin D on immune system function and regulation.
Vitamin D insufficiency has been linked with susceptibility to infection and
autoimmune diseases. The relationship between vitamin D deficiency and
risk of infections in early life is still under investigations . Objective: To
examine the effect of vitamin D supplementation in the first 6-months of life
on the immunity and risk of infections during the first year in infants .
Methods: A prospective controlled study included 99 full term infants
divided into two groups: group I included 48 infants supplemented with
daily 400 I.U vitamin D for 6-months and group II included 51 infants not
supplemented with vitamin D. Investigations needed for diagnosis of
respiratory, gastrointestinal tract, and urinary tract infections were
addressed every visit until the infants' first birth day. Two mls of maternal
blood were withdrawn for 25-hydroxy vitamin D assessment using
radioimmunoassay . Results: The incidence of infections totally were less
common in infants supplemented with daily vitamin D than those not
supplemented (p value = 0.01). There were significant negative correlations
between the incidence of respiratory and gastrointestinal infections and
maternal vitamin D levels (p value = 0.001, r= -0.65, versus p value =
0.001, r= -0.61 respectively).There were significant negative correlations
between the incidence of both respiratory and gastrointestinal infections and
gestational ages, weights of infants, normal vaginal delivery, or rural
residence. There were significant positive correlations between the
incidence of both respiratory and gastrointestinal infections and maternal
age, multigravida, neonatal dark skin and paternal smoking . Conclusions:
The findings support the importance of vitamin D supplementation for the
first 6-months of life as well as maintaining normal maternal serum vitamin
D levels during pregnancy for its importance for the skeletal system and
innate immunity in infants. |
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