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EG |
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| Egypt J Pediatr Allergy Immunol |
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2012 |
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10 |
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45-48 |
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ESP - 26 |
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Original articles |
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| Resolution of lupus-related left ventricular wall thickening and interstitial
lung disease in a child with pulsed steroids and cyclophosphamide |
| Dalia H. El-Ghoneimy |
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Omneya I. Youssef |
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| Cardiopulmonary involvement is one of the important manifestations of
systemic lupus erythematosus (SLE) that tends to be more common in adults
than children with SLE. SLE-related cardiopulmonary affection ranges from
subclinical to life threatening condition. Although increased left ventricular
mass and interstitial lung disease have been reported in association with
SLE, the reversibility of such conditions with treatment of SLE was not
sufficiently reported. Herein, we describe a female adolescent with SLE and
lupus nephritis class III who presented as well with moderate dyspnea,
tachycardia in absence of heart failure and hypertension. She had also
productive cough of whitish sputum, no fever and both sputum and blood
cultures were negative. Her echocardiography revealed left ventricular wall
hypertrophy with preserved systolic function, electrocardiogram showed
sinus tachycardia. Her pulmonary function tests revealed mild restrictive
pattern and high resolution computed tomography revealed veiling of both
lungs with increased attenuation and interstitial nodules with bilateral mild
pleural effusion. She received full dose prednisone and intravenous monthly
cyclophosphamide in addition to intravenous pulsed methylprednislone. She
gradually improved with complete resolution of her cardiopulmonary
disease and significant reduction of her proteinuria. In conclusion,
cardiopulmonary involvement in relation to SLE could be reversible with
adequate treatment leaving no residual damage. |
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