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| Egypt J Pediatr Allergy Immunol |
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2011 |
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9 |
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21-27 |
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ESP - 35 |
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Original articles |
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| Assessment of plasma and urinary transforming growth factor beta 1
(TGF-?1) in children with lupus nephritis |
| Sanaa M. Abdel Salam |
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Safaa HA. Saleh |
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Eman E. El-Shahawy |
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Hanaa Abdel Moety |
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| Background: Kidney disease is one of the most serious manifestations of
systemic lupus erythematosus (SLE). Despite the improvement in the medical
care of SLE in the past two decades, the prognosis of lupus nephritis remains
unsatisfactory. Transforming growth factor- ?1 (TGF-?1) is an immunosuppressive
cytokine, as it inhibits T and B cell proliferation and NK cell
cytotoxic activity .
Objective: The aim of this study was to assess serum and urinary TGF- ?1 levels
in children with SLE and their possible role in the renal involvement and
activity of the disease.
Study design: This cross sectional study was conducted in Nephrology Unit of
Pediatric Department, plus Outpatient Clinic of Rheumatology Department ,
Zagazig University Hospital during the year of 2010.
Methods: Twenty-five pediatric patients with SLE were randomly selected and
classified according to into 2 groups: Group (?): included 13 patients presented
with urinary abnormalities and/or disturbed renal function(active nephritis): 5
males, 8 females. Their mean age was 9.7±2.53 years and the mean disease
duration was 2.46±1.4 years. Group (??): included 12 patients presented by
lupus without nephritis : 5 males,7 females. Their mean age was 9.9±2.1 years
and the mean disease duration was 2.41±0.9 years. Control group(group ???):
Twenty healthy children of matched age and sex served as a control group
included 8 males ,12 females. Their mean age was 10.0±2.3 years.
Results: There was no significant difference among studied patients groups
regarding age, sex , disease duration and lupus therapy (p>0.05). There was a
significant difference between both groups regarding urinary albumin and
serum creatinine (2.76±0.97 and 1.96±0.84 mg/dl respectively) ,while there was
a high significant difference between them regarding C3 (47.3±12.5 and
76.6±6.6 mg/ml respectively) and anti double stranded DNA (anti-dsDNA)
(80.7±32.8 and 26.8±4.5 IU/ml respectively). Plasma TGF- ?1 showed
significantly lower levels in patients with active nephritis relative to other
groups, while urinary TGF- ?1 levels were significantly high in SLE patients
either with active or silent nephritis when compared with the control group.
Plasma TGF- ?1 showed a highly significant positive correlation with C3 and a
highly significant negative correlation with serum creatinine, urinary albumin,
anti dsDNA and SLE disease activity index (SLEDAI) score. While, urinary
TGF- ?1 had a significant negative correlation with C3 and a high significant
positive correlation with anti-dsDNA and SLEDAI score.
Conclusion: Low plasma TGF ?1 level and increased urinary TGF ?1 excretion
denotes active renal affection in children with SLE . |
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