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Egypt J Pediatr Allergy Immunol, (October 2017), Volume No. 15, Issue 02  
 
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Egypt J Pediatr Allergy Immunol 2017 ; 15 ( 02 ) : 63 - 68
, ESP - 239  
Original articles
Lymphocyte subtype dysregulation in a group of children with simple obesity
Hoda L. Elsayed,   Yasmin G. El Gendy   Nesrine M. Radwan   Botheina A. Farweez   Shimaa Fouda    
Background: Obesity as a global public health problem is increasing in prevalence. Reports showed that obese children are more liable to infection than lean ones; it was claimed that obese subjects have altered peripheral blood total lymphocyte counts in addition to reduced lymphocyte proliferative response to mitogen stimulation as well as dysregulated cytokine expression. Objective: This study aimed to evaluate the effect of childhood obesity on cell-mediated immunity as indicated by peripheral blood lymphocyte phenotyping. Methods: We enrolled 30 school-aged children (mean age 103.27 years). They comprised two groups; 20 obese children with a mean body mass index (BMI) of 39.2 12.5 and 10 matched control subjects with mean BMI of 18.4 1.9. They were subjected to detailed anthropometric evaluation including weight, height, and waist-hip ratio in addition to calculation of BMI, complete blood counting, and flow cytometric assessment of T-helper (CD4), T-cytotoxic/suppressor (CD8), and natural killer (CD56) cell counts. Results: The absolute lymphocyte (CD3) and natural killer cell (CD56) counts were comparable in both groups. However, the CD4%, CD8%, CD4/CD8 ratio were significantly lower in the obese children (p=0.02, 0.03, 0.015 respectively). A significant negative correlation could be elicited between the CD4 count and body weight, BMI, and a hip-waist ratio (p = 0.00); the same was observed for the CD4/CD8 ratio (p = 0.00). On the contrary, CD8 correlated positively to the body weight, BMI, and waist-hip ratio (p = 0.00 for each). Conclusion: Obesity has an impact on lymphocytic subset counts and further studies are needed to assess its effect on their function.